4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative · aromatic compound
4,11,11-Trimethyl-10-Methylidenetricyclo[5.3.1.01,5]Undecane
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentrations are kept low
- not applied to broken skin
- used by individuals without known allergies
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in conjunction with other fragrances
- applying to areas with compromised skin
- using in high concentrations
✕ Avoid If:
- you are pregnant or nursing
- you have a known fragrance allergy
- you experience irritation upon use
- you are using on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 5 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical creams, ointments. Monitor for allergic reactions when used in formulations.
Household
Cleaning products, air fresheners. Ensure proper ventilation when using products containing this ingredient.
Supplement
Dietary supplements. Consult a healthcare provider before use, especially if pregnant.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly due to limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact may result in significant irritation, thus classified as high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with no significant concerns.
- elderly — Generally well tolerated, but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known sensitivities. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
Evidence suggests moderate safety for use in cosmetics and food, though some individuals may react negatively.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2018) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization | SCCS Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests moderate safety for use in cosmetics and food, though some individuals may react negatively.
- Generally safe in low concentrations.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Requires caution due to potential sensitization.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2019
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted with some restrictions in cosmetics in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in cosmetics due to sensitization concerns.
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation.
It's advisable to consult a healthcare provider before use during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:32:29.080560Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.