57.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · masking agent · sensory enhancer
Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde (Hmpcc)
Molecular Formula
C13H22O2
Molecular Weight
210.31 g/mol
Category
fragrance ingredient
Bottom Line: Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde is generally considered safe in cosmetics, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- part of a well-formulated product
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have a history of allergies
✕ Avoid If:
- you are allergic to fragrance ingredients
- you have eczema or dermatitis
- you experience irritation after use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H22O2 |
| Molecular Weight | 210.31 g/mol |
| Log P | 1.7 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in well-formulated products to minimize irritation risk.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products containing this ingredient.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if you have skin sensitivities.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Hmpcc is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Hmpcc may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: Moderate
Eye contact with Hmpcc may cause moderate irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher absorption rates and sensitivity to chemicals.
- pregnant — Potential increased sensitivity to chemical exposures.
- sensitive_skin — Increased likelihood of adverse reactions.
✔ Well-Tolerated Groups
- general_adult — Typically have a higher tolerance to Hmpcc exposure.
- elderly — Generally well tolerated but should be monitored.
- breastfeeding — Use with caution; limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance to Hmpcc exposure. |
| pregnant | Moderate | Pregnant individuals may be more sensitive to chemical exposures. |
| infants_children | High | Children's skin is more permeable, increasing absorption risks. |
| breastfeeding | Low to Moderate | Limited data on Hmpcc transfer through breast milk. |
| elderly | Low | Elderly individuals may have varying sensitivities to chemicals. |
| sensitive_skin | High | Individuals with sensitive skin may react adversely to Hmpcc. |
Toxicology Data
3 Endpoints
Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde is a fragrance ingredient with potential sensitization risks.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Sensitization | Moderate sensitizer | Human patch test | GHS Category 1B | CIR Safety Assessment (2015) |
| LD50 Oral | Not established | Not available | Insufficient data | SCCS Opinion (2016) |
| Eye Irritation | Mild irritant | Rabbit eye test | GHS Category 2A | FDA Review (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde is a fragrance ingredient with potential sensitization risks.
- Used widely in cosmetic formulations.
- May cause allergic reactions in some individuals.
- Regulatory assessments indicate moderate safety concerns.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde
Year: 2016
Conclusion: Not safe for use in cosmetics due to sensitization potential.
View Full Report →
FDA
Report: Regulatory Status of Hydroxyisohexyl 3-&4-Cyclohexene Carboxaldehyde
Year: 2021
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Regulatory status varies; permitted in the US and Canada, restricted in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Not safe for use in cosmetics above 0.5%
United Kingdom
UK GovernmentRESTRICTED
Not safe for use in cosmetics above 0.5%
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It is a fragrance ingredient commonly used in cosmetics and household products.
It may cause irritation or allergic reactions in sensitive individuals; caution is advised.
Regulations vary; it is permitted in the US but restricted in the EU and UK.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:10:49.134655Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.