6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · emollient
2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane
Molecular Formula
C13H18O2
Molecular Weight
206.28 g/mol
Category
chemical compound
Bottom Line: 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane is generally considered safe in cosmetics, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken or irritated skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
✕ Avoid If:
- You are pregnant or nursing without consulting a doctor
- You have a known allergy to dioxanes or similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 g/mol |
| Boiling Point | 278.0°C |
| Log P | 2.7 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical ointments, creams. Consult a healthcare provider before use.
Household
Cleaning agents, air fresheners. Ensure good ventilation when using products.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Limited studies on 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane suggest moderate safety in cosmetics, but caution is advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for general population | CIR Safety Assessment (2015) |
| Sensitization | Non-sensitizing | Human clinical study | Low risk of sensitization | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited studies on 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane suggest moderate safety in cosmetics, but caution is advised.
- Potential skin irritant for sensitive individuals
- Limited long-term safety data available
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane
Year: 2018
Conclusion: Safety concerns noted for sensitive skin types.
View Full Report →
FDA
Report: Regulatory Status of 2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane
Year: 2020
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
2,4,6-Trimethyl-4-Phenyl-1,3-Dioxane is permitted in major jurisdictions with no specific restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation for sensitive skin types; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
It is commonly found in facial creams, sunscreens, and hair conditioners.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:48:08.622619Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.