10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · flavoring agent
1-Methyl-4-(4-Methylpent-3-Enyl)Cyclohex-3-Ene-1-Carbaldehyde
Molecular Formula
C14H22O
Molecular Weight
206.32 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in cosmetic formulations at low concentrations
- properly diluted in food applications
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- using in food products for the first time
- exposed to high concentrations in occupational settings
✕ Avoid If:
- you have known allergies to similar fragrance compounds
- you experience irritation upon initial use
- using in high concentrations without proper guidance
- applying to mucous membranes
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H22O |
| Molecular Weight | 206.32 g/mol |
| Log P | 3.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Ensure proper dilution to avoid adverse effects.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in medications.
Supplement
Aromatic supplements. Use cautiously and consult a professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this compound is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential toxicity at higher doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited safety data; potential risks should be evaluated.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks should be considered. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects is greater. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1-Methyl-4-(4-Methylpent-3-Enyl)Cyclohex-3-Ene-1-Carbaldehyde is generally safe in low concentrations, though some may experience sensitivities.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not determined | Not available | Insufficient data | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | SCCS Opinion (2021) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Methyl-4-(4-Methylpent-3-Enyl)Cyclohex-3-Ene-1-Carbaldehyde is generally safe in low concentrations, though some may experience sensitivities.
- Low concentrations are typically safe for cosmetic use.
- May cause allergic reactions in sensitive individuals.
- Regulatory status varies by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Generally safe for use in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Safety concerns noted for high concentrations; low concentrations are acceptable.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2019
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
None
Frequently Asked Questions
Generally safe in low concentrations, though some may experience irritation or allergies.
Yes, but it should be used within specified limits to ensure safety.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:36:59.383670Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.