5.0
ISS Score
C — Moderate caution — review exposure context
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate in organic synthesis
Trans-3-Methyl-5-Phenyl-2-Pentenenitrile
Molecular Formula
C12H13N
Molecular Weight
171.24 g/mol
Category
chemical compound
Bottom Line: Generally, Trans-3-Methyl-5-Phenyl-2-Pentenenitrile is considered safe for use in cosmetics and household products, though caution is advised.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Properly diluted in household products
- Used as directed on product labels
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing this ingredient
- You are pregnant or nursing
✕ Avoid If:
- You experience irritation or allergic reactions
- You are using it in high concentrations
- You have a known sensitivity to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H13N |
| Molecular Weight | 171.24 g/mol |
| Log P | 3.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, lotions. Use in moderation to avoid skin irritation.
Pharmaceutical
Topical treatments, medicated creams. Consult a healthcare provider for use in medications.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Supplement
Dietary supplements. Consult a doctor before using in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trans-3-Methyl-5-Phenyl-2-Pentenenitrile shows low dermal irritation potential based on available studies.
oral
oral
Risk Level: Moderate
Ingestion may lead to moderate toxicity; caution is advised with oral exposure.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure presents a low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation; protective measures are recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for toxicity.
- pregnant — Potential risks to fetal development; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally safe but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly may have altered sensitivity; monitor for adverse effects. |
Toxicology Data
3 Endpoints
Trans-3-Methyl-5-Phenyl-2-Pentenenitrile has limited safety data, with some concerns regarding skin irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | Mild irritant | Human patch test | Moderate concern for sensitive skin | CIR Safety Assessment (2018) |
| LD50 Oral | Not established | Not tested | Insufficient data for acute toxicity | CIR Safety Assessment (2018) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for allergic reactions | SCCS Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trans-3-Methyl-5-Phenyl-2-Pentenenitrile has limited safety data, with some concerns regarding skin irritation.
- Potential irritant for sensitive skin.
- Limited long-term safety data available.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Generally safe for use in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Requires further evaluation for potential sensitization.
View Full Report →
FDA
Report: Regulatory Status of Fragrance Ingredients
Year: 2021
Conclusion: No specific restrictions, but monitoring for safety is ongoing.
View Full Report →
Regulatory Status
Global
Regulatory status varies; permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to certain concentrations in cosmetics.
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO DATA
None
Frequently Asked Questions
While generally safe, it may cause irritation for sensitive skin types.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:08:14.381886Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.