10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative · flavoring agent
Methylcyclopentadecanone
Molecular Weight
224.4 g/mol
Category
fragrance
Bottom Line: Methylcyclopentadecanone is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have a history of allergies
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on broken skin
- you are using in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Weight | 224.4 g/mol |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally recognized as safe when used as intended.
Pharmaceutical
Topical medications, ointments. Consult a healthcare provider for sensitive skin use.
Household
Cleaning products, air fresheners. Ensure proper ventilation when using products containing this ingredient.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methylcyclopentadecanone is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation, but significant damage is unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate exposure without significant issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Elderly individuals typically tolerate exposure well. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methylcyclopentadecanone has been evaluated for safety in various applications, showing low toxicity in standard tests.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | Not irritating | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methylcyclopentadecanone has been evaluated for safety in various applications, showing low toxicity in standard tests.
- Low acute toxicity observed in animal studies.
- Generally safe for cosmetic and food use.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methylcyclopentadecanone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Methylcyclopentadecanone
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: Opinion on Methylcyclopentadecanone
Year: 2019
Conclusion: Safe for use in cosmetic products with restrictions.
View Full Report →
Regulatory Status
Global
Methylcyclopentadecanone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use in cosmetics must comply with SCCS opinion.
UK
UK GovernmentPERMITTED
Must comply with safety assessments.
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before use during pregnancy to ensure safety.
Possible side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:45:31.278233Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.