66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 4 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · fragrance component · flavoring agent
ETHANONE, 1-(1,2,3,4,5,6,7,8-OCTAHYDRO-2,3,8,8-
Category
organic compound
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations
- Formulated for specific applications
- Patch tested for skin sensitivity
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have known allergies to similar compounds
- You experience irritation or adverse reactions
- You are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Use in well-formulated products to minimize irritation.
Food
Flavoring agents, food preservatives. Generally safe when used within regulatory limits.
Pharmaceutical
Topical ointments, oral medications. Consult a healthcare professional for specific uses.
Supplement
Dietary supplements, herbal extracts. Use as directed and consult a doctor if unsure.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethanone is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of ethanone may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation; ensure good ventilation.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Increased sensitivity and potential risks to fetal development.
- sensitive_skin — Prone to irritation and allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
- breastfeeding — Use with caution; limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for ethanone exposure. |
| pregnant | Moderate | Pregnant individuals may be more sensitive to chemical exposures. |
| infants_children | Very High | Children's developing systems may react adversely to ethanone. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities to chemicals. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
4 Endpoints
Ethanone is generally considered safe in regulated uses, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Human patch test | Not a skin irritant | CIR Safety Assessment (2020) |
| Sensitization | Not sensitizing | Human clinical study | No sensitization observed | CIR Safety Assessment (2020) |
| Eye Irritation | Mild irritant | Rabbit - Draize test | Mild irritation potential | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethanone is generally considered safe in regulated uses, though individual reactions may vary.
- Widely used in cosmetics and food
- Regulatory assessments support safety
- Monitor for individual sensitivities
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethanone
Year: 2020
Conclusion: Ethanone is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethanone
Year: 2019
Conclusion: Ethanone is acceptable for use in food flavorings under specified conditions.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Ethanone is permitted as a food additive under specific regulations.
View Full Report →
Regulatory Status
Global
Ethanone is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use within specified limits
European Union
European CommissionPERMITTED
Use in food flavorings only
United Kingdom
UK GovernmentPERMITTED
Use in cosmetics and food as per EU guidelines
Canada
Health CanadaPERMITTED
Use in cosmetics and food under specified conditions
Frequently Asked Questions
Ethanone is generally safe, but individuals with sensitive skin should patch test first.
Consult a healthcare provider before using products with ethanone during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:58:52.042252Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.