4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative · aromatic compound
2,6,6-Trimethyl-8-Methylidenetricyclo[5.3.1.01,5]Undecane
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken or irritated skin
- Used in well-ventilated areas for household products
⚠ Use with Awareness If:
- You have a history of skin sensitivities or allergies
- Using in combination with other fragrances or irritants
- Pregnant or nursing, consult a healthcare provider
✕ Avoid If:
- You are allergic to similar fragrance compounds
- Using on children without prior testing
- You experience irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 4.9 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, food additives. Use in food is regulated; ensure compliance with local laws.
Pharmaceutical
Topical medications, ointments. Consult a healthcare provider for use in pharmaceuticals.
Household
Cleaning products, air fresheners. Use in well-ventilated areas to minimize inhalation risks.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2,6,6-Trimethyl-8-Methylidenetricyclo[5.3.1.01,5]Undecane is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; potential risks during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with no significant issues.
- elderly — Generally well tolerated, but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known allergies. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
Safety assessments indicate low toxicity for 2,6,6-Trimethyl-8-Methylidenetricyclo[5.3.1.01,5]Undecane in cosmetic and household uses.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data for classification | — |
| Skin Irritation | Non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2020) |
| Sensitization | Not sensitizing | Human sensitization study | No sensitization reactions reported | SCCS Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments indicate low toxicity for 2,6,6-Trimethyl-8-Methylidenetricyclo[5.3.1.01,5]Undecane in cosmetic and household uses.
- Low acute toxicity observed in animal studies.
- Generally safe for use in cosmetics and household products.
- Regulatory bodies have not identified significant risks.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2019
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring Substances
Year: 2021
Conclusion: No safety concerns at typical exposure levels.
View Full Report →
Regulatory Status
Global
Regulatory status is generally permissive across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in cosmetics, though patch testing is recommended for sensitive individuals.
Yes, it is permitted in food flavorings, but must comply with local regulations.
While generally safe, some individuals may experience irritation or allergic reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:55:35.334662Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.