66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · flavoring agent · aromatic compound
BENZENEPROPANAL, 4-METHOXY-.ALPHA.-METHYL-
Category
fragrance compound
Bottom Line: Generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations typical for fragrances
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using in combination with other fragrances
✕ Avoid If:
- You have a known allergy to fragrance compounds
- You experience irritation upon use
- Using in high concentrations
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Use in moderation to avoid skin irritation.
Food
Flavoring agents, beverages. Generally safe in food applications at low levels.
Supplement
Dietary supplements with flavoring. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 4-Methoxy-.alpha.-Methyl-benzenepropanal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 4-Methoxy-.alpha.-Methyl-benzenepropanal may pose moderate risks due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 4-Methoxy-.alpha.-Methyl-benzenepropanal can cause significant irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- breastfeeding — Use with caution; limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
4-Methoxy-alpha-methyl-benzenepropanal is a fragrance compound with moderate safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
4-Methoxy-alpha-methyl-benzenepropanal is a fragrance compound with moderate safety data.
- Used in cosmetics and food flavoring
- Potential for skin sensitization
- Regulatory reviews indicate moderate safety
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at typical concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Safety concerns noted for high concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Considered safe for use in food at specified levels.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Use in cosmetics must comply with SCCS guidelines
United Kingdom
UK GovernmentPERMITTED
Must comply with UK cosmetic regulations
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Yes, it is permitted in food flavoring at regulated levels.
Some individuals may experience allergic reactions; caution is advised.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:07:09.435168Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.