7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
plasticizer · intermediate · solvent
Ethylene Dodecanedioate
Molecular Formula
C14H24O4
Molecular Weight
256.34 g/mol
Category
chemical compound
Bottom Line: Ethylene Dodecanedioate is generally considered safe for use in cosmetics and food, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- used in concentrations below recommended limits
- not combined with known irritants
- properly formulated in products
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using multiple products containing similar compounds
- you are pregnant or nursing
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on broken skin
- you have a known sensitivity to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O4 |
| Molecular Weight | 256.34 g/mol |
| Log P | 3.6 |
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe in cosmetics when used as directed.
Food
Food additives, flavoring agents. Considered safe in food applications within limits.
Pharmaceutical
Topical medications, oral formulations. Use in pharmaceuticals is regulated and monitored.
Household
Cleaning agents, air fresheners. Safe for household use when properly diluted.
Supplement
Dietary supplements, nutraceuticals. Use with caution; consult a healthcare provider.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to ethylene dodecanedioate is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of ethylene dodecanedioate may pose moderate risks, depending on dosage.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with ethylene dodecanedioate can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but individual health factors may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Ethylene Dodecanedioate has been evaluated for safety in various applications, showing low toxicity and minimal irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human clinical study | No sensitization reactions reported | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethylene Dodecanedioate has been evaluated for safety in various applications, showing low toxicity and minimal irritation.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethylene Dodecanedioate
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Ethylene Dodecanedioate
Year: 2018
Conclusion: Considered safe for use as a food additive.
View Full Report →
FDA
Report: Regulatory Status of Ethylene Dodecanedioate
Year: 2020
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Ethylene Dodecanedioate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test products containing it.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:31:45.658326Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.