8.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · stabilizer
(4-Propan-2-Ylcyclohexyl)Methanol
Molecular Formula
C10H20O
Molecular Weight
156.26 g/mol
Category
chemical compound
Bottom Line: Generally, (4-Propan-2-Ylcyclohexyl)Methanol is considered safe for use in cosmetics and household products, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H20O |
| Molecular Weight | 156.26 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 3 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical analgesics, anti-inflammatory creams. Consult a healthcare provider for use in medications.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (4-Propan-2-Ylcyclohexyl)Methanol is generally low risk, but irritation may occur.
oral
oral
Risk Level: Moderate
Ingestion of (4-Propan-2-Ylcyclohexyl)Methanol poses moderate risks, including potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Ocular exposure can cause significant irritation and potential damage to the eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Limited studies suggest (4-Propan-2-Ylcyclohexyl)Methanol is safe in cosmetics, but caution is advised for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited studies suggest (4-Propan-2-Ylcyclohexyl)Methanol is safe in cosmetics, but caution is advised for sensitive individuals.
- Generally recognized as safe in cosmetics.
- Potential for skin irritation in sensitive users.
- Limited long-term safety data available.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (4-Propan-2-Ylcyclohexyl)Methanol
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on (4-Propan-2-Ylcyclohexyl)Methanol
Year: 2022
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
FDA
Report: Regulatory Status of (4-Propan-2-Ylcyclohexyl)Methanol
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe.
View Full Report →
Regulatory Status
Global
Generally permitted in the US and UK, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific regulations found
Frequently Asked Questions
While generally safe, it may cause irritation for sensitive skin types.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:36:39.957435Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.