66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · stabilizer
BENZENEPENTANOL, .GAMMA.-METHYL-
Category
chemical compound
Bottom Line: Generally, benzenepentanol is considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or allergic reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe for topical use, but patch test recommended.
Food
Flavoring agents, food additives. Use within established food safety limits.
Pharmaceutical
Topical ointments, medicated creams. Consult healthcare provider for use in medications.
Household
Cleaning agents, air fresheners. Follow usage instructions to minimize exposure.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepentanol is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of benzenepentanol may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with benzenepentanol can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Benzenepentanol is used in various applications, with moderate safety assessments indicating low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | EFSA Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzenepentanol is used in various applications, with moderate safety assessments indicating low toxicity.
- Used in cosmetics and food products.
- Moderate concern for sensitive individuals.
- Regulatory reviews support its safe use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzenepentanol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Benzenepentanol
Year: 2018
Conclusion: Considered safe as a food additive within specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Benzenepentanol is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use within specified limits.
EU
European CommissionPERMITTED
Allowed in cosmetics and food under specific conditions.
UK
UK GovernmentPERMITTED
Regulated similarly to EU standards.
CA
Health CanadaPERMITTED
Allowed in cosmetics and food with limits.
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test.
Yes, it is permitted as a food additive within specified limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:03:21.890277Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.