7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · aromatic compound
(E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol
Molecular Formula
C11H14O
Molecular Weight
162.23 g/mol
Category
chemical compound
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits.
- Not applied to broken or irritated skin.
- Used in well-ventilated areas.
⚠ Use with Awareness If:
- You have sensitive skin or allergies.
- Using in combination with other active ingredients.
- Pregnant or breastfeeding.
✕ Avoid If:
- You have a known allergy to similar compounds.
- Using on open wounds or severe skin conditions.
- Ingesting in large amounts without guidance.
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H14O |
| Molecular Weight | 162.23 g/mol |
| Log P | 2.7 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food additives. Considered safe for use in food products within regulatory limits.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision to avoid adverse reactions.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use, especially if pregnant.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol may cause irritation, indicating moderate risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant adverse effects reported. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children may increase risk of adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Research indicates (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol is generally safe for use in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol is generally safe for use in cosmetics and food.
- Low toxicity in animal studies.
- Potential skin irritant for sensitive individuals.
- Regulatory reviews support safe use in specified concentrations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol
Year: 2022
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on (E)-2-Methyl-3-(4-Methylphenyl)Prop-2-En-1-Ol
Year: 2020
Conclusion: Acceptable daily intake established for food use.
View Full Report →
Regulatory Status
Global
Regulatory status varies, generally permitted with some restrictions in cosmetics. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED WITH RESTRICTIONS
Max 1% in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution.
Ingesting in small amounts is typically safe, but consult a healthcare provider first.
Possible side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:23:48.089020Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.