6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · aroma compound
Rose Ketone-3
Molecular Formula
C13H20O
Molecular Weight
192.30 g/mol
Category
fragrance
Bottom Line: Rose Ketone-3 is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- used in well-formulated products
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are allergic to similar compounds
✕ Avoid If:
- you have a known allergy to rose-derived ingredients
- you experience irritation upon use
- you are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O |
| Molecular Weight | 192.30 g/mol |
| Solubility | 1 ml in 10 ml 95% alcohol (in ethanol) |
| Log P | 3.4 |
Common Use Cases
3 Categories
Cosmetic
Fragrance oils, skin creams, lotions. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, beverages, confectionery. Use in food is regulated; ensure compliance with guidelines.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Rose Ketone-3 is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Rose Ketone-3 may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but caution is advised in sensitive individuals.
ocular
ocular
Risk Level: High
Direct eye contact with Rose Ketone-3 can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of skin irritation and adverse reactions.
- sensitive_skin — Increased likelihood of irritation and allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but individual sensitivities may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Children's skin is more sensitive, increasing risk of irritation. |
| breastfeeding | Low to Moderate | Limited data on effects during breastfeeding; caution is advised. |
| elderly | Low | Elderly individuals may have varying skin sensitivities. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Rose Ketone-3 has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2019) |
| Sensitization | non-sensitizing | Human patch test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Rose Ketone-3 has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant irritant or sensitizing effects reported.
- Generally recognized as safe in regulated uses.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Rose Ketone-3
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Rose Ketone-3
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: Opinion on Rose Ketone-3
Year: 2019
Conclusion: No safety concerns at recommended use levels.
View Full Report →
Regulatory Status
Global
Rose Ketone-3 is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Yes, it is permitted as a flavoring agent in food under regulatory guidelines.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:52:54.685834Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.