7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · plasticizer
Trimethylhexyl Acetate
Molecular Formula
C11H22O2
Molecular Weight
186.29 g/mol
Category
chemical compound
Bottom Line: Trimethylhexyl Acetate is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated cosmetic products
- Concentration is within recommended limits
- Not applied to broken skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in conjunction with other fragrances
- Pregnant or nursing
✕ Avoid If:
- You have known allergies to similar compounds
- Using on irritated or damaged skin
- Ingesting or using in food products without proper guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H22O2 |
| Molecular Weight | 186.29 g/mol |
| Log P | 3.5 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic formulations when used as directed.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to avoid inhalation risks.
Food
Flavoring agents. Consult food safety guidelines before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trimethylhexyl Acetate is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Trimethylhexyl Acetate may pose moderate risks, including gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure to Trimethylhexyl Acetate may cause respiratory irritation in some individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Limited data on safety during pregnancy; use caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally safe, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Trimethylhexyl Acetate has been assessed for safety in cosmetics and household products, with limited data on food use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2015) |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2015) |
| Sensitization | Non-sensitizing | Human clinical study | Low concern for sensitization | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trimethylhexyl Acetate has been assessed for safety in cosmetics and household products, with limited data on food use.
- Generally recognized as safe in cosmetics
- Limited food safety data available
- Potential for skin irritation in sensitive individuals
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Trimethylhexyl Acetate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 10%.
View Full Report →
EFSA
Report: Scientific Opinion on Trimethylhexyl Acetate
Year: 2018
Conclusion: Insufficient data to determine safety in food applications.
View Full Report →
FDA
Report: Regulatory Status of Trimethylhexyl Acetate
Year: 2020
Conclusion: Permitted for use in cosmetics; no specific food regulations.
View Full Report →
Regulatory Status
Global
Trimethylhexyl Acetate is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution and perform a patch test.
Its use in food is not well established; consult food safety guidelines before use.
Potential side effects include skin irritation for sensitive individuals; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:18:06.039001Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.