66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · fragrance ingredient · skin conditioning agent · preservative
(E)-2-METHOXY-4-(PROP-1-ENYL)PHENOL
Category
phenolic compound
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not combined with known irritants
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to phenolic compounds
- Using on broken or irritated skin
- Ingesting in large quantities
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, sunscreens. Generally safe in cosmetic formulations when used appropriately.
Food
Flavoring agents, herbal teas. Considered safe as a food additive within regulatory limits.
Pharmaceutical
Topical ointments, prescription creams. Use under medical supervision for therapeutic applications.
Supplement
Herbal supplements, nutraceuticals. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (E)-2-Methoxy-4-(prop-1-enyl)phenol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (E)-2-Methoxy-4-(prop-1-enyl)phenol may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with (E)-2-Methoxy-4-(prop-1-enyl)phenol can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and potential for adverse effects.
- pregnant — Limited data; caution is advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
Research indicates (E)-2-Methoxy-4-(prop-1-enyl)phenol is generally safe for topical and food use, though caution is advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2015) |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2015) |
| Sensitization | Non-sensitizing | Human clinical trials | Low concern for sensitization | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (E)-2-Methoxy-4-(prop-1-enyl)phenol is generally safe for topical and food use, though caution is advised.
- Widely used in cosmetics and food products
- Potential for skin irritation in sensitive individuals
- Regulatory assessments support its safety
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (E)-2-Methoxy-4-(prop-1-enyl)phenol
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on (E)-2-Methoxy-4-(prop-1-enyl)phenol
Year: 2018
Conclusion: Considered safe as a food additive within specified limits.
View Full Report →
FDA
Report: Food Additive Status of (E)-2-Methoxy-4-(prop-1-enyl)phenol
Year: 2020
Conclusion: Permitted for use in food applications.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for topical use, though some may experience irritation.
Typically safe in food products within regulatory limits, but check labels.
Discontinue use immediately and consult a healthcare professional if needed.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:54:05.145545Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.