6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · stabilizer · active ingredient · skin conditioning agent
6-[2-[2-[(4,6-Diamino-1,3,5-Triazin-2-Yl)Sulfanyl]Ethoxy]Ethylsulfanyl]-1,3,5-Triazine-2,4-Diamine
Molecular Formula
C13H24O2
Molecular Weight
212.33 g/mol
Category
chemical compound
Bottom Line: Generally considered safe for use in cosmetics and pharmaceuticals, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not combined with known irritants
- Patch tested prior to widespread use
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to triazines
- Experiencing skin irritation or redness
- Using on broken or compromised skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H24O2 |
| Molecular Weight | 212.33 g/mol |
| Log P | 3.5 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, serums, sunscreens. Use in moderation and perform patch tests.
Pharmaceutical
Topical treatments, antibiotic creams. Consult a healthcare provider before use.
Supplement
Dietary supplements, nutraceuticals. Follow dosage recommendations carefully.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but irritation may occur in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential toxicity at high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation or damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any adverse reactions. |
Toxicology Data
3 Endpoints
Limited studies suggest moderate safety for topical use, but caution is advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for general population | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human clinical trial | Low risk of sensitization | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited studies suggest moderate safety for topical use, but caution is advised.
- Potential for skin irritation in sensitive individuals
- Regulatory reviews indicate moderate safety
- More research needed on long-term effects
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 6-[2-[2-[(4,6-Diamino-1,3,5-Triazin-2-Yl)Sulfanyl]Ethoxy]Ethylsulfanyl]-1,3,5-Triazine-2,4-Diamine
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 6-[2-[2-[(4,6-Diamino-1,3,5-Triazin-2-Yl)Sulfanyl]Ethoxy]Ethylsulfanyl]-1,3,5-Triazine-2,4-Diamine
Year: 2022
Conclusion: Safety concerns noted for sensitive skin types.
View Full Report →
FDA
Report: Regulatory Status of 6-[2-[2-[(4,6-Diamino-1,3,5-Triazin-2-Yl)Sulfanyl]Ethoxy]Ethylsulfanyl]-1,3,5-Triazine-2,4-Diamine
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to specific products
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should exercise caution.
Consult a healthcare provider before using products with this ingredient if pregnant.
Discontinue use immediately and consult a dermatologist if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:48:13.129222Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.