8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance component · solvent · intermediate in chemical synthesis
(5e)-3-Methylcyclopentadec-5-En-1-One
Molecular Formula
C16H28O
Molecular Weight
236.39 g/mol
Category
organic compound
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not combined with known irritants
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation or adverse reactions
- Using on broken or compromised skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 g/mol |
| Log P | 5.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food additives. Considered safe for food use within established limits.
Pharmaceutical
Topical medications, oral supplements. Use under medical supervision, especially in sensitive populations.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (5e)-3-Methylcyclopentadec-5-En-1-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (5e)-3-Methylcyclopentadec-5-En-1-One may pose moderate risks due to limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Insufficient Data
Limited data on ocular exposure makes risk assessment challenging.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity increases risk of adverse effects.
- pregnant — Limited safety data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited studies on safety during pregnancy warrant caution. |
| infants_children | High | Higher sensitivity in infants and children increases risk. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Safety assessments indicate moderate concern for sensitive individuals, but generally safe for use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | N/A | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | SCCS Opinion (2022) |
| Sensitization | Not sensitizing | Human clinical trial | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments indicate moderate concern for sensitive individuals, but generally safe for use.
- CIR supports its use in cosmetics.
- EFSA has evaluated its safety in food applications.
- No significant toxicity reported in studies.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (5e)-3-Methylcyclopentadec-5-En-1-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on (5e)-3-Methylcyclopentadec-5-En-1-One
Year: 2020
Conclusion: Considered safe for food use within established limits.
View Full Report →
SCCS
Report: Opinion on (5e)-3-Methylcyclopentadec-5-En-1-One
Year: 2022
Conclusion: No safety concerns when used as intended in cosmetics.
View Full Report →
Regulatory Status
Global
Generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should proceed with caution.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:43:03.779955Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.