7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · aroma enhancer
1-(2,6,6-Trimethylcyclohexen-1-Yl)Pent-1-En-3-One
Molecular Formula
C14H22O
Molecular Weight
206.32 g/mol
Category
fragrance compound
Bottom Line: Generally regarded as safe when used in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food flavoring within regulatory limits
- Not applied to broken skin or mucous membranes
⚠ Use with Awareness If:
- You have a history of fragrance allergies
- Using products on sensitive skin
- Ingesting large amounts in food products
✕ Avoid If:
- You are pregnant or breastfeeding without consulting a doctor
- You have known sensitivities to similar compounds
- Using in high concentrations in personal care products
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H22O |
| Molecular Weight | 206.32 g/mol |
| Boiling Point | 102.0°C |
| Log P | 3.4 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavored beverages, baked goods, confectionery. Generally safe when used as a flavoring agent.
Supplement
Flavoring agents in dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally considered low risk, but irritation may occur in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, but prolonged exposure may lead to respiratory irritation.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but monitor for sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1-(2,6,6-Trimethylcyclohexen-1-Yl)Pent-1-En-3-One is a fragrance compound with various applications in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitive individuals | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-(2,6,6-Trimethylcyclohexen-1-Yl)Pent-1-En-3-One is a fragrance compound with various applications in cosmetics and food.
- Used primarily for its scent in cosmetic products.
- Regulatory assessments indicate moderate safety.
- Potential for allergic reactions in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Safety concerns exist for certain populations; use with caution.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Considered safe for use in food flavoring within established limits.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use within cosmetic regulations
UK
UK GovernmentPERMITTED
Complies with UK regulations
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in low concentrations, though some may experience irritation.
Typically safe in food products, but consult a healthcare provider for large amounts.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:25:40.812082Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.