7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance · stabilizer · emollient
Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol
Molecular Formula
C10H20O2
Molecular Weight
172.26 g/mol
Category
chemical compound
Bottom Line: Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol is generally considered safe in cosmetics and food, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using alongside other active ingredients
- pregnant or nursing
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on children without guidance
- you have known sensitivities to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H20O2 |
| Molecular Weight | 172.26 g/mol |
| Log P | 1.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision; monitor for reactions.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Ocular exposure to Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol is considered high risk and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but health factors vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol has been evaluated for safety in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol has been evaluated for safety in cosmetics and food applications.
- Generally recognized as safe in cosmetics.
- Limited data on long-term effects.
- Further studies recommended for sensitive populations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol
Year: 2020
Conclusion: Considered safe as a food additive within specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Tetrahydro-Methyl-Methylpropyl)-Pyran-4-Ol is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use within specified limits
EU
European CommissionPERMITTED
Use in cosmetics and food additives
UK
UK GovernmentPERMITTED
Use in cosmetics and food additives
CA
Health CanadaPERMITTED
Use in cosmetics and food products
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include irritation or allergic reactions; discontinue use if these occur.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:01:09.552904Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.