55.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · stabilizer
BENZENE, 1,2-DIMETHOXY-4-(1E)-1-PROPENYL-
Category
aromatic compound
Bottom Line: Benzene, 1,2-dimethoxy-4-(1E)-1-propenyl- is generally considered safe in low concentrations, though caution is advised due to potential irritants.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated cosmetic products
- Concentration is below regulatory limits
- Applied to intact skin only
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing this ingredient
- You are pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Using in high concentrations
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Fragrances, skin creams, hair products. Use in low concentrations to minimize irritation risk.
Pharmaceutical
Topical medications, ointments. Ensure proper formulation to avoid adverse effects.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to reduce inhalation risk.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Dermal exposure may cause irritation or sensitization in some individuals.
oral
oral
Risk Level: High
Ingestion can lead to serious health effects, including toxicity.
inhalation
inhalation
Risk Level: Moderate
Inhalation may cause respiratory irritation and other health issues.
ocular
ocular
Risk Level: Low to Moderate
Eye contact may cause mild irritation; flushing may be required.
Who Should Use or Avoid
⚠ Higher Risk Groups
- pregnant — Increased susceptibility to chemical exposure effects.
- infants_children — Higher risk due to developing systems.
✔ Well-Tolerated Groups
- general_adult — Typically have a higher tolerance to exposure.
- elderly — May experience moderate effects; use caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults typically have a higher tolerance to exposure compared to vulnerable groups. |
| pregnant | High | Pregnant individuals may be more susceptible to chemical exposure effects. |
| infants_children | Very High | Children's developing systems may be more affected by toxic substances. |
| breastfeeding | Moderate | Lactating individuals should be cautious as substances can transfer to milk. |
| elderly | Low to Moderate | Older adults may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Benzene, 1,2-dimethoxy-4-(1E)-1-propenyl- has limited safety data, with some concerns regarding skin irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Moderate acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | Irritating | Rabbit - Dermal application | Causes skin irritation | SCCS Opinion (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | Low sensitization potential | FDA Regulatory Status (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzene, 1,2-dimethoxy-4-(1E)-1-propenyl- has limited safety data, with some concerns regarding skin irritation.
- Limited data on long-term exposure effects.
- Potential irritant for sensitive skin.
- Regulatory limits are in place for safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzene Derivatives
Year: 2018
Conclusion: Generally safe in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Benzene Derivatives
Year: 2020
Conclusion: Requires caution due to potential skin irritation.
View Full Report →
FDA
Report: Regulatory Status of Benzene Derivatives
Year: 2021
Conclusion: Permitted in cosmetics under specific conditions.
View Full Report →
Regulatory Status
Global
Benzene, 1,2-dimethoxy-4-(1E)-1-propenyl- is permitted with restrictions in several jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Limited to specific concentrations
European Union
European CommissionRESTRICTED
Must comply with SCCS recommendations
United Kingdom
UK GovernmentPERMITTED
Follow EU guidelines post-Brexit
Canada
Health CanadaNO DATA
No specific regulations identified
Frequently Asked Questions
It may cause irritation for sensitive skin types; patch testing is recommended.
Possible side effects include skin irritation and allergic reactions in some individuals.
Yes, there are concentration limits and guidelines for safe use in cosmetics.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:37:42.053369Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.