7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · solvent · stabilizer
Cis-3-Hexenyl Salicylate
Molecular Formula
C13H16O3
Molecular Weight
220.26 g/mol
Category
fragrance ingredient
Bottom Line: Cis-3-Hexenyl Salicylate is generally considered safe in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetics
- included in food products within regulatory limits
- not applied to broken skin
- not used by individuals with known allergies to salicylates
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to areas exposed to sunlight
- using in high concentrations
✕ Avoid If:
- you are pregnant or breastfeeding without consulting a doctor
- you have a history of fragrance allergies
- you experience irritation or adverse reactions
- using in products for children without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H16O3 |
| Molecular Weight | 220.26 g/mol |
| Solubility | Freely soluble (in ethanol) |
| Log P | 4.4 |
Common Use Cases
5 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, beverages. Permitted in food products within regulatory limits.
Pharmaceutical
Topical creams, ointments. Use cautiously in medicinal products.
Household
Air fresheners, cleaning products. Safe in household products when used appropriately.
Supplement
Flavoring in dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cis-3-Hexenyl Salicylate is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; caution is advised, especially in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation; immediate rinsing is recommended if exposure occurs.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse effects.
- pregnant — Limited data; caution is warranted.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risk.
- breastfeeding — Low to moderate risk; monitor infant.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cis-3-Hexenyl Salicylate is evaluated for safety in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2015) |
| Sensitization | low sensitization potential | Human sensitization study | Low concern for sensitization | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cis-3-Hexenyl Salicylate is evaluated for safety in cosmetics and food, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in specified uses.
- Potential for skin sensitization in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2012
Conclusion: Cis-3-Hexenyl Salicylate is safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics with appropriate concentration limits.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2018
Conclusion: Considered safe for use in food flavoring applications.
View Full Report →
Regulatory Status
Global
Cis-3-Hexenyl Salicylate is permitted in cosmetics and food across major jurisdictions with concentration limits. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Concentration limits apply
UK
UK GovernmentPERMITTED
Concentration limits apply
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Possible side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:47:11.392904Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.