66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance · intermediate · stabilizer
CYCLOPENTANONE, 2,2,5-TRIMETHYL-5-PENTYL-
Category
chemical compound
Bottom Line: Cyclopentanone, 2,2,5-trimethyl-5-pentyl- is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations.
- Ingested in small amounts as a flavoring agent.
- Applied to intact skin without prior irritation.
⚠ Use with Awareness If:
- You have sensitive skin or allergies.
- Using products containing this ingredient for the first time.
- You are pregnant or nursing.
✕ Avoid If:
- You have known allergies to similar compounds.
- You experience irritation or adverse reactions.
- Using in high concentrations without proper guidance.
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, hair products. Generally safe in cosmetic products when used appropriately.
Food
Flavoring agents, food additives. Typically safe in food at regulated levels.
Pharmaceutical
Topical medications, formulation solvents. Use in pharmaceuticals should follow regulatory guidelines.
Household
Cleaning agents, air fresheners. Use with caution in household products to avoid irritation.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclopentanone, 2,2,5-trimethyl-5-pentyl- is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of cyclopentanone can lead to gastrointestinal irritation and other adverse effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation; use in well-ventilated areas is advised.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Limited data on safety during pregnancy; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- breastfeeding — Generally low risk but consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more susceptible to adverse effects; use with caution. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; exercise caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclopentanone, 2,2,5-trimethyl-5-pentyl- has been evaluated for safety in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclopentanone, 2,2,5-trimethyl-5-pentyl- has been evaluated for safety in cosmetics and food applications.
- Generally recognized as safe in low concentrations.
- Potential for irritation in sensitive individuals.
- Regulatory assessments vary by jurisdiction.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclopentanone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclopentanone
Year: 2018
Conclusion: Acceptable daily intake established for food use.
View Full Report →
FDA
Report: Regulatory Status of Cyclopentanone
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specified conditions.
View Full Report →
Regulatory Status
Global
Cyclopentanone is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, cyclopentanone is safe in cosmetics at low concentrations, but individual sensitivities may vary.
Yes, it is permitted in food as a flavoring agent, but should be used within established limits.
If irritation occurs, discontinue use immediately and consult a healthcare professional for advice.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:48:46.214014Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.