56.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
BENZENEPROPANAL, .ALPHA.-METHYL-4-(2-METHYLPROPYL)-
Category
fragrance
Bottom Line: Generally, benzenepropanal is considered safe for use in cosmetics and food, though caution is advised due to potential sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in well-ventilated areas
- Not combined with known irritants
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using multiple products containing fragrances
- You experience irritation after use
✕ Avoid If:
- You have a known allergy to fragrance ingredients
- You are using on children without testing
- You have respiratory issues that may be aggravated
- You experience adverse reactions after use
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical creams, ointments. Monitor for allergic reactions in sensitive individuals.
Supplement
Aromatic supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepropanal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of benzenepropanal may pose moderate risks due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with benzenepropanal can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but health status should be considered.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is warranted. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Benzenepropanal has been evaluated for safety in cosmetics and food applications, with varying results based on concentration and use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2020) |
| Sensitization | positive in sensitization tests | Guinea Pig - Maximization test | Potential sensitizer | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzenepropanal has been evaluated for safety in cosmetics and food applications, with varying results based on concentration and use.
- Generally safe in low concentrations.
- Potential for skin irritation exists.
- Regulatory reviews are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Requires further study on sensitization potential.
View Full Report →
EFSA
Report: Evaluation of Flavoring Substances
Year: 2019
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Benzenepropanal is generally permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:08:52.607273Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.