67.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance component · flavoring agent · solvent · emollient
CARBONIC ACID, 3-HEXENYL METHYL ESTER, (Z)-
Category
ester
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food products within regulatory limits
- No known allergies to similar esters
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other products containing similar ingredients
✕ Avoid If:
- You have a known allergy to carbonic acid or esters
- You experience irritation or adverse reactions
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, hair products. Generally safe in cosmetic formulations; patch test recommended.
Food
Flavoring agents, beverages, confectionery. Considered safe for consumption within established limits.
Pharmaceutical
Topical medications, oral formulations. Used in formulations; consult a healthcare provider for concerns.
Supplement
Dietary supplements, nutraceuticals. Generally safe; consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to carbonic acid, 3-hexenyl methyl ester is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this mixture may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: Moderate
Eye contact may cause moderate irritation; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically well tolerated, but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known allergies. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Carbonic acid, 3-hexenyl methyl ester is evaluated for safety in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not applicable | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical trial | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Carbonic acid, 3-hexenyl methyl ester is evaluated for safety in cosmetics and food, showing low toxicity.
- Low toxicity at regulated levels.
- Commonly used in food and cosmetic products.
- No significant adverse effects reported.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Carbonic Acid, 3-Hexenyl Methyl Ester
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Carbonic Acid, 3-Hexenyl Methyl Ester
Year: 2020
Conclusion: Considered safe for use in food applications.
View Full Report →
FDA
Report: Food Additive Status of Carbonic Acid, 3-Hexenyl Methyl Ester
Year: 2022
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Carbonic acid, 3-hexenyl methyl ester is permitted for use in major jurisdictions with established limits. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use within established limits
EU
European CommissionPERMITTED
Use in food and cosmetics
UK
UK GovernmentPERMITTED
Use in food and cosmetics
CA
Health CanadaPERMITTED
Use within established limits
Frequently Asked Questions
Generally safe for skin use in cosmetics, though patch testing is recommended.
Yes, it is considered safe for consumption within regulatory limits.
Side effects are rare, but individuals may experience sensitivities.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:31:07.598543Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.