6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
Octahydro-Methoxy-Tetramethyl-Methanoazulene
Molecular Formula
C16H28O
Molecular Weight
236.39 g/mol
Category
fragrance
Bottom Line: Octahydro-Methoxy-Tetramethyl-Methanoazulene is generally considered safe in cosmetics and food, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin or mucous membranes
- Used in food products within established limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using multiple products containing fragrances
✕ Avoid If:
- You have a known allergy to similar fragrance compounds
- You experience irritation or adverse reactions
- Using in high concentrations without proper formulation
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 g/mol |
| Log P | 4.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, beverages. Use within established flavoring limits.
Pharmaceutical
Topical creams, ointments. Monitor for skin reactions; use as directed.
Supplement
Dietary supplements with flavoring. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Octahydro-Methoxy-Tetramethyl-Methanoazulene is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this mixture may pose moderate risks, particularly due to limited data on toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but data on long-term effects is insufficient.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause irritation, indicating a higher risk for ocular exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy necessitates caution. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities to ingredients. |
Toxicology Data
3 Endpoints
Octahydro-Methoxy-Tetramethyl-Methanoazulene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2021) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Octahydro-Methoxy-Tetramethyl-Methanoazulene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies
- Generally recognized as safe in cosmetic formulations
- Limited data on long-term exposure effects
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 1%
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring Group Evaluation
Year: 2019
Conclusion: Considered safe for use in food flavoring within specified limits.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Safe for use in cosmetic products with restrictions.
View Full Report →
Regulatory Status
Global
Octahydro-Methoxy-Tetramethyl-Methanoazulene is generally permitted across major jurisdictions with specific guidelines. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Use in cosmetics must comply with SCCS recommendations.
United Kingdom
UK GovernmentPERMITTED
Must comply with UK cosmetic regulations.
Canada
Health CanadaPERMITTED
Must comply with Canadian regulations.
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:25:15.992740Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.