6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Fragrance ingredient · Solvent · Flavoring agent
Rhodinol
Also known as: Rhodinol, 2-Phenyl-2-methyl-1-propanol
Molecular Formula
C10H20O
Molecular Weight
156.26 g/mol
Category
Fragrance
Bottom Line: Rhodinol is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin or open wounds
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on irritated or damaged skin
- Consuming in excessive amounts
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H20O |
| Molecular Weight | 156.26 g/mol |
| Solubility | soluble (in ethanol) |
| Log P | 3.5 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, beverages. Safe for use in food within established limits.
Pharmaceutical
Topical creams, ointments. Use cautiously in pharmaceutical applications.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Rhodinol is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Rhodinol may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children may have heightened sensitivity to Rhodinol.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by adults.
- elderly — Generally well tolerated, but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for Rhodinol exposure. |
| pregnant | Moderate | Limited data on Rhodinol effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to Rhodinol's effects. |
| breastfeeding | Low to Moderate | Limited data on Rhodinol transfer in breast milk. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Rhodinol has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Rhodinol has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Generally recognized as safe in low concentrations.
- Potential for skin irritation in sensitive individuals.
- Regulatory bodies support its use with guidelines.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Rhodinol
Year: 2012
Conclusion: Rhodinol is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Rhodinol
Year: 2015
Conclusion: Rhodinol is safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on Rhodinol
Year: 2018
Conclusion: Rhodinol is safe for use in cosmetic products.
View Full Report →
Regulatory Status
Global
Rhodinol is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Rhodinol may cause irritation in sensitive individuals; patch testing is recommended.
Yes, Rhodinol is permitted as a flavoring agent in food within regulatory limits.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:51:54.066915Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.