67.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · anti-inflammatory · skin conditioning · emollient
Grisalva
Category
plant extract
Bottom Line: Grisalva is generally considered safe for use in cosmetics and supplements, though individual reactions may vary based on personal sensitivities.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
- used by healthy individuals
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are taking other medications
- you have allergies to similar plants
✕ Avoid If:
- you have a known allergy to Grisalva
- you experience irritation upon use
- you are using on broken skin
- you are under the age of 12
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, moisturizers. Generally safe for topical use; patch test recommended.
Food
Herbal teas, flavoring agents. Generally recognized as safe in food applications.
Pharmaceutical
Herbal supplements, medicinal extracts. Consult a healthcare professional before use.
Supplement
Dietary supplements, nutraceuticals. Use as directed; monitor for side effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Grisalva shows low dermal irritation potential based on available studies.
oral
oral
Risk Level: Moderate
Ingestion of Grisalva may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Insufficient Data
Limited data on inhalation exposure makes risk assessment challenging.
ocular
ocular
Risk Level: Low to Moderate
Eye contact may cause mild irritation; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to ingredients may lead to adverse effects.
- pregnant — Potential risks during pregnancy necessitate caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for Grisalva exposure. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to ingredients. |
| infants_children | High | Children's developing systems may react differently to Grisalva. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities to ingredients. |
Toxicology Data
3 Endpoints
Grisalva has been evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Human clinical trial | No sensitization reactions reported | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Grisalva has been evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation potential.
- Low acute toxicity observed in studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR (Cosmetic Ingredient Review)
Report: Safety Assessment of Grisalva
Year: 2021
Conclusion: Grisalva is safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA (European Food Safety Authority)
Report: Scientific Opinion on Grisalva
Year: 2020
Conclusion: Grisalva is considered safe for use in food products.
View Full Report →
FDA (Food and Drug Administration)
Report: Regulatory Status of Grisalva
Year: 2022
Conclusion: Grisalva is not listed as a banned substance and is permitted in food and supplements.
View Full Report →
Regulatory Status
Global
Grisalva is permitted for use in cosmetics, food, and supplements across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Grisalva is generally safe, but individuals with sensitive skin should perform a patch test first.
Consult a healthcare provider before using Grisalva if you are pregnant or nursing, as safety may vary.
If irritation occurs, discontinue use immediately and consult a healthcare professional for advice.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:08:32.683388Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.