47.0
ISS Score
Poor — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · stabilizer · emollient
BICYCLO[3.3.1]NONANE, 2-ETHOXY-2,6,6-TRIMETHYL-9-
Category
organic compound
Bottom Line: Generally, bicyclo[3.3.1]nonane, 2-ethoxy-2,6,6-trimethyl-9- is considered safe for use in cosmetics and household products, though caution is advised.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products designed for topical application
- Not used on broken or irritated skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or nursing
✕ Avoid If:
- You are allergic to similar organic compounds
- Using on open wounds or mucous membranes
- You experience irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical ointments, transdermal patches. Consult a healthcare professional before use.
Household
Cleaning agents, air fresheners. Ensure proper ventilation during use.
Supplement
Dietary supplements, herbal extracts. Consult a doctor before starting any new supplement.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to bicyclo[3.3.1]nonane is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of bicyclo[3.3.1]nonane may pose moderate risks due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: Moderate
Eye contact with bicyclo[3.3.1]nonane may cause irritation, posing moderate risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but individual health factors should be considered.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
Bicyclo[3.3.1]nonane, 2-ethoxy-2,6,6-trimethyl-9- shows moderate safety in cosmetic applications, though data is limited.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | SCCS Opinion (2022) |
| Sensitization | no sensitization observed | Guinea Pig - Maximization Test | Low sensitization potential | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[3.3.1]nonane, 2-ethoxy-2,6,6-trimethyl-9- shows moderate safety in cosmetic applications, though data is limited.
- Limited studies on human exposure.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[3.3.1]nonane Derivatives
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Bicyclo[3.3.1]nonane in Cosmetics
Year: 2022
Conclusion: Requires further study to confirm long-term safety.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[3.3.1]nonane
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Bicyclo[3.3.1]nonane is generally permitted in cosmetics, with ongoing reviews in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
Generally, it is considered safe for skin use, though patch testing is recommended.
Caution is advised; consider patch testing before full application.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:25:50.068152Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.