66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · emulsifier · preservative · fragrance · pH adjuster
ACETIC ACID, (CYCLOHEXYLOXY)-, 2-PROPENYL ESTER
Category
Chemical Compound
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not combined with known irritants
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in large quantities
- Mixing with other active ingredients
✕ Avoid If:
- You are pregnant or breastfeeding
- You have a known allergy to acetic acid
- Using on broken or irritated skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial cleansers, hair conditioners, exfoliating scrubs. Use in moderation to avoid skin irritation.
Food
Pickling solutions, salad dressings, sauces. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical ointments, antiseptics. Follow dosage instructions to minimize risks.
Household
Cleaning agents, deodorizers. Ensure proper ventilation when using.
Supplement
Dietary supplements, probiotics. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this ingredient is generally low risk for most individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact can cause irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by healthy adults.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Acetic acid (cyclohexyloxy)-2-propenyl ester is generally safe in regulated uses, though caution is advised for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Mildly irritating | Rabbit - Draize test | Moderate concern for sensitive skin | ECHA REACH Registration |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | Low concern for sensitization | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Acetic acid (cyclohexyloxy)-2-propenyl ester is generally safe in regulated uses, though caution is advised for sensitive individuals.
- Used in various cosmetic and food products
- Potential for skin irritation in sensitive users
- Regulatory assessments support safe use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Acetic Acid Derivatives
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Acetic Acid
Year: 2018
Conclusion: Considered safe for food use within established limits.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2020
Conclusion: Permitted as a food additive under specific conditions.
View Full Report →
Regulatory Status
Global
Generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use within established limits
EU
European CommissionPERMITTED
Use in cosmetics and food within limits
UK
UK GovernmentPERMITTED
Use in cosmetics and food within limits
CA
Health CanadaPERMITTED
Use in cosmetics and food within limits
Frequently Asked Questions
Generally safe in cosmetics, though some may experience irritation.
Yes, it's safe in food products within regulated limits.
Potential for irritation in sensitive individuals; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:28:32.915946Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.