6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · stabilizer
8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane
Molecular Formula
C15H24O2
Molecular Weight
236.35 g/mol
Category
fragrance ingredient
Bottom Line: 8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in well-ventilated areas
- Formulated by reputable manufacturers
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using multiple products containing fragrances
- You experience irritation after use
✕ Avoid If:
- You have known allergies to fragrance ingredients
- You are using products on children
- You have respiratory conditions like asthma
- You experience adverse reactions after use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24O2 |
| Molecular Weight | 236.35 g/mol |
| Log P | 3 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Use in food is regulated; ensure compliance.
Pharmaceutical
Topical creams, ointments. Use in pharmaceuticals should follow guidelines.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: Insufficient Data
Limited data exists on ocular exposure risks for this substance.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Children may be more susceptible to adverse effects due to their developing systems. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
Toxicology Data
3 Endpoints
8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Regulatory assessments support safe use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2017
Conclusion: No safety concerns at typical exposure levels.
View Full Report →
Regulatory Status
Global
8-Isopropyl-6-Methylbicyclooctenyl-Dioxolane is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution and perform a patch test.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:51:57.039429Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.