6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · fixative · solvent
Hexahydro-Methanoindenyl Propionate
Molecular Formula
C13H18O2
Molecular Weight
206.28 g/mol
Category
fragrance
Bottom Line: Hexahydro-Methanoindenyl Propionate is generally considered safe in cosmetics, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated cosmetic products
- Concentration is within recommended limits
- No known allergies to similar fragrance compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products with fragrances
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to this ingredient
- Experiencing skin irritation after use
- Using on broken or damaged skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.28 g/mol |
| Log P | 2.6 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if unsure about use.
Household
Air fresheners, cleaning products. Ensure good ventilation when using products.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Skin contact with Hexahydro-Methanoindenyl Propionate is generally safe for most individuals.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Breathing in vapors may cause mild irritation; caution is advised in poorly ventilated areas.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Generally well tolerated, but monitor for sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Hexahydro-Methanoindenyl Propionate is a fragrance ingredient with limited safety data, primarily used in cosmetics.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | non-irritating | Human Patch Test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Human Sensitization Study | Low concern for sensitization | SCCS Opinion (2020) |
| LD50 Oral | Not established | N/A | Insufficient data | FDA Review (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Hexahydro-Methanoindenyl Propionate is a fragrance ingredient with limited safety data, primarily used in cosmetics.
- Limited data on skin sensitization
- Potential for irritation in sensitive individuals
- Regulatory assessments ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Requires further investigation for potential sensitization.
View Full Report →
FDA
Report: Fragrance Ingredient Safety
Year: 2022
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Hexahydro-Methanoindenyl Propionate is permitted in cosmetics in major jurisdictions, with ongoing reviews in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further safety data
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It is a fragrance ingredient commonly used in cosmetics and household products.
While generally safe, individuals with sensitive skin should patch test before use.
Yes, it is permitted in cosmetics in the US, UK, and Canada, but under review in the EU.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:07:30.597284Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.