66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · skin conditioning agent · antioxidant · aromatic agent
Citrus Aurantium Peel Oil
Also known as: Bitter Orange Peel Oil, Citrus Aurantium Oil
Category
essential oil
Bottom Line: Citrus Aurantium Peel Oil is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in diluted form in cosmetics
- consumed in small amounts as a flavoring agent
- not applied to broken skin
- used by adults without known allergies
⚠ Use with Awareness If:
- you have citrus allergies
- you are pregnant or breastfeeding
- you have sensitive skin
- you are taking medications that may interact
✕ Avoid If:
- you have a known allergy to citrus fruits
- you are using products that increase photosensitivity
- you experience irritation upon application
- you are under 18 years of age without adult supervision
Chemical Properties
| Property | Value |
|---|---|
| Solubility | soluble in oils, insoluble in water |
Common Use Cases
4 Categories
Cosmetic
Facial creams, body lotions, fragrances. Dilute before applying to skin to minimize irritation risk.
Food
Flavoring agents, beverages, confectionery. Generally safe in small amounts; check for allergies.
Pharmaceutical
Dietary supplements, herbal remedies. Consult a healthcare provider before use, especially if pregnant.
Supplement
Weight loss supplements, energy boosters. Use with caution; potential for side effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Citrus Aurantium Peel Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Citrus Aurantium Peel Oil can pose risks, particularly in high doses, due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of Citrus Aurantium Peel Oil is typically safe but may cause respiratory irritation in some individuals.
ocular
ocular
Risk Level: High
Eye contact with Citrus Aurantium Peel Oil can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to sensitivity.
- pregnant — Limited safety data; consult healthcare provider.
- sensitive_skin — Increased likelihood of irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- breastfeeding — Generally safe but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity to essential oils; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on effects during breastfeeding; use cautiously. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Citrus Aurantium Peel Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2012) |
| Sensitization | not sensitizing | Human patch test | No sensitization reactions reported | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Citrus Aurantium Peel Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Generally recognized as safe in cosmetics and food.
- May cause skin irritation in sensitive individuals.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Citrus Aurantium Peel Oil
Year: 2012
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Citrus Aurantium
Year: 2013
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
FDA
Report: Citrus Aurantium in Dietary Supplements
Year: 2015
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Citrus Aurantium Peel Oil is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, it is safe for skin use when diluted, but some may experience irritation.
Yes, it is typically safe in food products, but check for allergies first.
Some individuals may experience skin irritation or allergic reactions; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:03:28.141773Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.