7.0
ISS Score
D+ — Higher caution — limited data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
exfoliant · anti-inflammatory
Salicylic Acid
Molecular Formula
C7H6O3
Molecular Weight
138.12 g/mol
Category
Preservative
Bottom Line: Salicylic Acid is generally considered effective for certain skin conditions, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Formulated for specific skin types
- Patch tested prior to use
⚠ Use with Awareness If:
- You have sensitive skin
- You are using other exfoliants
- You experience irritation
✕ Avoid If:
- You are allergic to salicylates
- You have open wounds
- You are pregnant or breastfeeding without consulting a doctor
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C7H6O3 |
| Molecular Weight | 138.12 g/mol |
| Solubility | soluble in alcohol and ether, slightly soluble in water |
Common Use Cases
1 Categories
Cosmetic
General products. Verify suitability for specific formulation and intended use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Salicylic Acid is generally considered low risk when used as directed in cosmetic formulations.
oral
oral
Risk Level: Insufficient Data
Oral ingestion of Salicylic Acid can be harmful and should be avoided. Limited data is available on its safety when ingested.
inhalation
inhalation
Risk Level: Insufficient Data
Inhalation exposure to Salicylic Acid is not well studied. Caution is advised to avoid potential respiratory irritation.
ocular
ocular
Risk Level: Insufficient Data
Ocular exposure to Salicylic Acid may cause irritation. It is advisable to avoid contact with eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- Pregnant Individuals — Limited data on safety during pregnancy.
- Infants and Children — Safety data for young children is limited.
✔ Well-Tolerated Groups
- General Adult Population — Generally well tolerated when used as directed.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| General Adult Population | Low | Generally well tolerated in adults when used in appropriate concentrations. |
| Pregnant Individuals | Insufficient Data | Limited data on the safety of Salicylic Acid during pregnancy. |
| Infants and Children | Insufficient Data | Safety data for young children is limited. Use caution. |
Toxicology Data
0 Endpoints
Salicylic Acid is widely used in skincare, particularly for acne treatment, though individual responses may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Salicylic Acid is widely used in skincare, particularly for acne treatment, though individual responses may vary.
- Effective for acne and exfoliation
- May cause dryness or irritation
- Consult a dermatologist for personalized advice
Switch to Detailed mode to view full scientific assessments and citation database.
Pending formal assessment
Report: No formal safety assessment identified
Year: 2026
Conclusion: This ingredient has not been formally assessed by major regulatory or scientific bodies based on available records.
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Max 2% in rinse-off hair products; Max 0.5% in other products (except as preservative) Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED - ANNEX III ENTRY 98
Max 2% in rinse-off hair products; Max 0.5% in other products (except as preservative)
United States
FDAOTC DRUG - ACNE TREATMENT UP TO 2%; WART REMOVER UP TO 17%
Acne: 0.5-2%; Dandruff/Psoriasis: 1.8-3%; Wart remover: up to 17%
Frequently Asked Questions
Salicylic Acid is commonly used in skincare products for treating acne and exfoliating the skin.
While generally safe for many, individuals with sensitive skin should use caution and consult a dermatologist.
Consult a healthcare professional before using Salicylic Acid during pregnancy due to limited safety data.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| v1.0.0 | 2023-10-01T00:00:00Z | — | Initial creation |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.