6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
1-Oxaspiro[4.5]Decan-2-One
Molecular Formula
C9H14O2
Molecular Weight
154.21 g/mol
Category
chemical compound
Bottom Line: 1-Oxaspiro[4.5]Decan-2-One is generally considered safe in cosmetics and pharmaceuticals, though caution is advised in food applications.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using it in food products without proper guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C9H14O2 |
| Molecular Weight | 154.21 g/mol |
| Log P | 1.8 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, sunscreens. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical ointments, medicated creams. Used in formulations; follow dosage guidelines.
Food
Flavoring agents, food additives. Use with caution; limited safety data available.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 1-Oxaspiro[4.5]Decan-2-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 1-Oxaspiro[4.5]Decan-2-One may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with 1-Oxaspiro[4.5]Decan-2-One may cause significant irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — May tolerate with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
1-Oxaspiro[4.5]Decan-2-One has limited safety data, primarily in cosmetics and pharmaceuticals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human patch test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Oxaspiro[4.5]Decan-2-One has limited safety data, primarily in cosmetics and pharmaceuticals.
- Used in various cosmetic formulations.
- Safety assessments indicate moderate concern in food use.
- Regulatory reviews are ongoing in several jurisdictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-Oxaspiro[4.5]Decan-2-One
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 1-Oxaspiro[4.5]Decan-2-One
Year: 2022
Conclusion: Insufficient data for safe use in food applications.
View Full Report →
EFSA
Report: Evaluation of 1-Oxaspiro[4.5]Decan-2-One as a food additive
Year: 2023
Conclusion: Not enough evidence to support safe use in food.
View Full Report →
Regulatory Status
Global
Regulatory status varies; permitted in the US, restricted in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited to cosmetic use
UK
UK GovernmentRESTRICTED
Limited to cosmetic use
CA
Health CanadaNO_DATA
No data available
Frequently Asked Questions
Generally, yes, but always perform a patch test first.
Use with caution; patch test is recommended for sensitive skin.
Caution is advised; limited safety data for food use exists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:39:10.975412Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.