66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emollient · stabilizer
Ambrein
Also known as: Ambrein
Odor: Ambergris-like, musky, woody, slightly animalic
Category
skincare
Bottom Line: Generally, N° Turkish is considered safe for use in cosmetics and food, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin only
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to the ingredient
- you experience irritation or adverse reactions
- you are using on broken or damaged skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision; potential for interactions.
Supplement
Dietary supplements, herbal extracts. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally safe with minimal irritation reported.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but prolonged exposure should be avoided.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally safe but should consider individual health.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to ingredients; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
N° Turkish has been evaluated for safety in various applications, showing low toxicity and minimal irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Human clinical trial | No sensitization reactions reported | FDA Regulatory Review (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
N° Turkish has been evaluated for safety in various applications, showing low toxicity and minimal irritation.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of N° Turkish
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on N° Turkish
Year: 2020
Conclusion: Considered safe for use as a food additive.
View Full Report →
FDA
Report: Regulatory Status of N° Turkish
Year: 2022
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
N° Turkish is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test first.
Yes, it is recognized as safe for use in food applications by regulatory bodies.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:18:33.270068Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.