55.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Preservative · Antioxidant · Fragrance · Solvent
PHENOL, 2-METHOXY-, REACTION PRODUCTS WITH 2,2-
Category
Chemical Compound
Bottom Line: Generally, phenol, 2-methoxy-, reaction products with 2,2- are considered safe in regulated uses, though caution is advised based on concentration and application.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied to intact skin without irritation
- Used in products with proper labeling and safety data
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or nursing women should consult a healthcare provider
✕ Avoid If:
- You have a known allergy to phenolic compounds
- Using on broken or irritated skin
- Ingesting products containing this ingredient
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, preservatives. Ensure compliance with food safety regulations.
Pharmaceutical
Topical antiseptics, medicated creams. Consult a healthcare professional for use in medications.
Household
Cleaning agents, disinfectants. Follow safety instructions on product labels.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Skin contact with this mixture may cause irritation or allergic reactions in some individuals.
oral
oral
Risk Level: High
Ingestion of this mixture can lead to serious health effects, including toxicity.
inhalation
inhalation
Risk Level: Moderate
Breathing in vapors may cause respiratory irritation and other health issues.
ocular
ocular
Risk Level: Very High
Eye contact can result in severe irritation or damage; immediate flushing is necessary.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Increased risk of complications from chemical exposure.
✔ Well-Tolerated Groups
- general_adult — Typically can handle moderate exposure with precautions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults may have varying sensitivities to this mixture based on skin type and health. |
| pregnant | High | Pregnant individuals may be more susceptible to chemical exposure effects. |
| infants_children | Very High | Children's developing systems may react more severely to this mixture. |
| breastfeeding | Moderate | Potential transfer of chemicals through breast milk is a concern. |
| sensitive_skin | High | Individuals with sensitive skin may experience heightened reactions. |
Toxicology Data
3 Endpoints
Phenol, 2-methoxy-, reaction products with 2,2- show moderate safety in cosmetic and household applications based on current assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | SCCS Opinion (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Phenol, 2-methoxy-, reaction products with 2,2- show moderate safety in cosmetic and household applications based on current assessments.
- Regulatory bodies have assessed safety for various uses.
- Concentration and formulation impact safety outcomes.
- Consumer awareness is crucial for safe usage.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Phenol Derivatives
Year: 2020
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Phenolic Compounds
Year: 2021
Conclusion: Safety concerns at high concentrations; recommend monitoring.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2019
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Regulatory assessments indicate permitted use with some restrictions in cosmetics. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It is commonly used in cosmetics, food flavorings, and household products.
Generally safe when used as directed, but always check for personal sensitivities.
Potential side effects include skin irritation in sensitive individuals; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:29:42.305740Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.