66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent · emollient
ISOPENTYL ACETATE
Also known as: isoamyl acetate, pentyl acetate
Molecular Weight
100.16 g/mol
Category
ester
Bottom Line: Isopentyl acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic products
- consumed in food products within regulatory limits
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have a history of skin allergies
- you are pregnant or breastfeeding
- you are using other skin irritants
- you have respiratory conditions
✕ Avoid If:
- you are allergic to esters
- you have sensitive skin
- you are using it in high concentrations
- you experience irritation upon use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Weight | 100.16 g/mol |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, hair sprays. Use in moderation to avoid skin irritation.
Food
Flavoring agents, confectionery. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for use in medications.
Household
Air fresheners, cleaning products. Ensure good ventilation when using household products.
Supplement
Flavoring in dietary supplements. Use only as directed on product labels.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Isopentyl acetate is generally safe for skin contact in low concentrations.
oral
oral
Risk Level: Moderate
Ingestion of isopentyl acetate can cause gastrointestinal irritation and should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of vapors may cause mild respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause irritation; avoid direct exposure to prevent discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- pregnant — Caution is advised due to limited data on effects during pregnancy.
- infants_children — Higher sensitivity to chemical exposures; keep away from children.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in low concentrations.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure to isopentyl acetate. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use cautiously. |
| elderly | Low | Elderly individuals may have varying sensitivities to chemicals. |
Toxicology Data
3 Endpoints
Isopentyl acetate is an ester with various applications in cosmetics and food, generally recognized as safe.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Isopentyl acetate is an ester with various applications in cosmetics and food, generally recognized as safe.
- Used for its pleasant aroma in products.
- Regulatory bodies have assessed its safety.
- Sensitivity may vary among individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Isopentyl Acetate
Year: 2015
Conclusion: Isopentyl acetate is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Isopentyl Acetate
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Isopentyl acetate is permitted as a food additive.
View Full Report →
Regulatory Status
Global
Isopentyl acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, isopentyl acetate is safe for skin use in low concentrations, but some may experience irritation.
Yes, it is permitted as a flavoring agent in food products under regulatory guidelines.
If irritation occurs, discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:13:45.885674Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.