66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 4 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · skin conditioning agent · antioxidant · aromatic agent
Citrus Aurantium Flower Oil
Also known as: Bitter Orange Flower Oil, Neroli Oil
Category
essential oil
Bottom Line: Citrus Aurantium Flower Oil is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in diluted form
- applied topically in small amounts
- used in food products within recommended limits
⚠ Use with Awareness If:
- you have citrus allergies
- you are pregnant or nursing
- you are using other skin irritants
✕ Avoid If:
- you have sensitive skin
- you are allergic to citrus fruits
- you are taking medications that may interact
Chemical Properties
| Property | Value |
|---|---|
| Solubility | soluble in alcohol and oils |
Common Use Cases
4 Categories
Cosmetic
Facial creams, body lotions, perfumes. Perform a patch test before widespread use to check for sensitivity.
Food
Flavoring agents, beverages, confectionery. Generally safe when used within food safety guidelines.
Pharmaceutical
Herbal supplements, topical ointments. Consult a healthcare provider before use, especially if on medication.
Supplement
Dietary supplements, herbal teas. Use as directed and consult a healthcare professional if unsure.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Citrus Aurantium Flower Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Citrus Aurantium Flower Oil may pose risks, particularly in high doses, due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of the oil is typically safe, but prolonged exposure may lead to respiratory irritation.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Potential hormonal effects; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally safe but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential hormonal effects. |
| infants_children | High | Higher sensitivity to essential oils; risk of irritation or adverse effects. |
| breastfeeding | Low to Moderate | Limited data on effects during lactation; caution is advised. |
| elderly | Low | Generally well tolerated, but may have increased sensitivity. |
Toxicology Data
4 Endpoints
Citrus Aurantium Flower Oil is evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2012) |
| Sensitization | not sensitizing | Human clinical study | No sensitization reactions reported | CIR Safety Assessment (2012) |
| Eye Irritation | mild irritation | Rabbit - Draize test | Mild irritation observed | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Citrus Aurantium Flower Oil is evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation potential.
- Low acute toxicity observed in studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR (Cosmetic Ingredient Review)
Report: Safety Assessment of Citrus Aurantium Flower Oil
Year: 2012
Conclusion: Citrus Aurantium Flower Oil is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA (European Food Safety Authority)
Report: Scientific Opinion on the safety of Citrus Aurantium
Year: 2015
Conclusion: Citrus Aurantium is safe for use in food at specified limits.
View Full Report →
FDA (Food and Drug Administration)
Report: Citrus Aurantium Flower Oil Regulatory Status
Year: 2021
Conclusion: Generally recognized as safe when used in food and cosmetics according to guidelines.
View Full Report →
Regulatory Status
Global
Citrus Aurantium Flower Oil is permitted for use in cosmetics and food across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Citrus Aurantium Flower Oil may cause irritation in sensitive individuals; patch testing is recommended before use.
Consult a healthcare provider before using Citrus Aurantium Flower Oil during pregnancy to ensure safety.
Potential side effects include skin irritation and allergic reactions; discontinue use if any adverse effects occur.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:02:25.446290Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.