66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · stabilizer
BICYCLO[2.2.1]HEPTAN-2-ONE, 1,7,7-TRIMETHYL-
Category
fragrance
Bottom Line: Generally regarded as safe in low concentrations, though some individuals may experience sensitivity when used in cosmetics.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- applied to intact skin without prior irritation
- used in food products within regulatory limits
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to broken or irritated skin
✕ Avoid If:
- you are pregnant or breastfeeding without consulting a doctor
- you have a known allergy to similar compounds
- using in high concentrations in food or cosmetics
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, creams. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food applications within limits.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements. Use under guidance, especially in sensitive populations.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Bicyclo[2.2.1]heptan-2-one is generally well tolerated with minimal irritation.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation; immediate rinsing is recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to irritation and adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally safe but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate exposure without significant effects. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to exposure; risk of irritation is higher. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl- is generally safe in regulated uses, though caution is advised for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl- is generally safe in regulated uses, though caution is advised for sensitive individuals.
- Used primarily as a fragrance in cosmetics and food.
- May cause skin irritation in sensitive individuals.
- Regulatory assessments support its safe use in specified concentrations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2018
Conclusion: Considered safe for use in food flavoring at specified limits.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2020
Conclusion: Permitted for use in food products under specific regulations.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use in food and cosmetics within specified limits.
European Union
European CommissionPERMITTED
Allowed in cosmetics and food flavorings.
United Kingdom
UK GovernmentPERMITTED
Regulated under UK food and cosmetic laws.
Canada
Health CanadaPERMITTED
Allowed in cosmetics and food products.
Frequently Asked Questions
Generally safe in low concentrations, though some may experience irritation.
Yes, it is permitted in food flavorings under regulatory limits.
Some individuals may experience skin sensitivity or allergic reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:22:11.427593Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.