56.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · solvent · flavoring agent
BENZENEPROPANAL, 4-(1-METHYLETHYL)-
Category
fragrance
Bottom Line: Generally regarded as safe in low concentrations, though some individuals may experience sensitivity when used in cosmetics.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic products
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to areas with high absorption
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- using in high concentrations
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food at regulated levels.
Pharmaceutical
Topical medications, ointments. Monitor for allergic reactions when used topically.
Household
Air fresheners, cleaning products. Ensure good ventilation when using products.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepropanal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of benzenepropanal may pose moderate risks due to potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with benzenepropanal can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — May tolerate with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Moderate | Potential for transfer through breast milk; limited data available. |
| elderly | Low to Moderate | Elderly individuals may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Evidence suggests 4-(1-methylethyl)benzenepropanal is generally safe in regulated uses, though sensitivity may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | non-irritating | Human patch test | Low concern for skin irritation | CIR Safety Assessment (2015) |
| LD50 Oral | Not established | Not applicable | Insufficient data for acute toxicity | EFSA Opinion (2020) |
| Sensitization | may cause sensitization | Human clinical studies | Moderate concern for sensitization | SCCS Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests 4-(1-methylethyl)benzenepropanal is generally safe in regulated uses, though sensitivity may occur.
- Used widely in cosmetics and food flavoring.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments indicate safe use at specified levels.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Allergens
Year: 2019
Conclusion: May cause allergic reactions; use with caution.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2020
Conclusion: Considered safe for use in food at specified levels.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted with some restrictions in cosmetics. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics due to sensitization potential.
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe in low concentrations, but may cause irritation for sensitive individuals.
Yes, it is permitted in food flavoring at regulated levels, though caution is advised.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:05:15.191266Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.