7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
Tetrahydrolinalool
Also known as: 3,7-Dimethyl-1,6-octadien-3-ol, Tetrahydrolinalool
Molecular Formula
C10H22O
Molecular Weight
158.28 g/mol
Category
fragrance
Bottom Line: Tetrahydrolinalool is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other fragrance products
✕ Avoid If:
- you have a known allergy to linalool
- you experience irritation after use
- you are using on children under 3 years
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H22O |
| Molecular Weight | 158.28 g/mol |
| Solubility | 1 ml in 2 ml 70% alcohol (in ethanol) |
| Log P | 3.3 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics but may cause irritation in sensitive individuals.
Food
Flavoring agents, beverages. Used as a flavoring agent; ensure low concentrations.
Pharmaceutical
Topical creams, ointments. Used in topical formulations; monitor for skin reactions.
Household
Air fresheners, cleaning products. Safe in household products; avoid direct skin contact.
Supplement
Herbal supplements. Limited use in supplements; consult a healthcare provider.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Tetrahydrolinalool is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Low to Moderate
Ingestion of Tetrahydrolinalool is typically safe in small amounts, but excessive intake may lead to gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low
Inhalation exposure to Tetrahydrolinalool is generally considered safe, though high concentrations may cause respiratory irritation.
ocular
ocular
Risk Level: Moderate
Contact with eyes may cause irritation; caution is advised to avoid exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to skin and respiratory irritants.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally safe but may require caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for Tetrahydrolinalool with minimal adverse effects. |
| pregnant | Low to Moderate | Limited data on the effects during pregnancy; caution is advised. |
| infants_children | Moderate | Children may be more sensitive to ingredients; use with care. |
| breastfeeding | Low | Generally considered safe, but limited data on transfer through milk. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities; monitor for reactions. |
Toxicology Data
3 Endpoints
Tetrahydrolinalool is a fragrance compound with low toxicity and is widely used in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2015) |
| Sensitization | positive in sensitization tests | Human sensitization study | Potential allergen for some individuals | EFSA Opinion (2010) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Tetrahydrolinalool is a fragrance compound with low toxicity and is widely used in cosmetics and food.
- Low acute toxicity in animal studies.
- Potential allergen for sensitive individuals.
- Regulatory bodies support its safe use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Linalool
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Linalool
Year: 2015
Conclusion: Considered safe for use in cosmetics with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2010
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Tetrahydrolinalool is permitted in major jurisdictions with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, it may cause irritation for some individuals with sensitive skin.
Yes, it is permitted as a flavoring agent in food at regulated concentrations.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:00:03.965268Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.