56.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
BICYCLO[2.2.1]HEPTANE, 2,2-DIMETHYL-3-METHYLENE-
Category
organic compound
Bottom Line: Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene- is generally considered safe in regulated uses, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- applied to intact skin without irritation
- used in food products within regulatory limits
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other active ingredients
- exposed to high temperatures during use
✕ Avoid If:
- you are pregnant or breastfeeding without consulting a doctor
- you have a known allergy to similar compounds
- using in high concentrations without proper formulation
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, hair styling products. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, food additives. Use within established food safety limits.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare provider for medicinal use.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to avoid inhalation risks.
Supplement
Dietary supplements, herbal products. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to bicyclo[2.2.1]heptane is generally low risk, but irritation may occur.
oral
oral
Risk Level: Moderate
Ingestion of bicyclo[2.2.1]heptane may pose moderate risks, including gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but prolonged exposure may lead to respiratory issues.
ocular
ocular
Risk Level: High
Ocular exposure can cause significant irritation and potential damage to the eye.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children are particularly sensitive to chemical exposures.
- pregnant — Pregnant individuals may experience heightened sensitivity.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated by healthy adults.
- elderly — Typically tolerated but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance to chemical exposures. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to chemicals. |
| infants_children | Very High | Children are more vulnerable to chemical exposures due to their developing systems. |
| breastfeeding | Moderate | Lactating individuals should be cautious as chemicals can transfer through milk. |
| elderly | Low to Moderate | Elderly individuals may have decreased resilience to chemical exposures. |
Toxicology Data
3 Endpoints
Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene- shows moderate safety in cosmetic applications, with limited data for food use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene- shows moderate safety in cosmetic applications, with limited data for food use.
- Moderate safety for cosmetic use based on CIR assessments.
- Limited food safety data available.
- Potential for irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[2.2.1]heptane Derivatives
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Bicyclo[2.2.1]heptane in Food
Year: 2020
Conclusion: Insufficient data to establish a safe level for food use.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[2.2.1]heptane
Year: 2022
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Bicyclo[2.2.1]heptane is permitted in cosmetics but has restrictions in food applications. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in food products
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific regulations identified
Frequently Asked Questions
Generally, yes, but individuals with sensitive skin should exercise caution.
It's best to consult a healthcare provider before using such products during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:23:08.470303Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.