6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
Dihydroterpinyl Acetate
Molecular Formula
C12H22O2
Molecular Weight
198.30 g/mol
Category
fragrance
Bottom Line: Dihydroterpinyl Acetate is generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other fragrance products
✕ Avoid If:
- you have a known allergy to terpenes
- you experience irritation or allergic reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O2 |
| Molecular Weight | 198.30 g/mol |
| Log P | 3.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, beverages. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical ointments, medicated creams. Use cautiously in pharmaceuticals; consult a healthcare provider.
Supplement
Dietary supplements. Limited use in supplements; check for allergies.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dihydroterpinyl Acetate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal discomfort; moderate caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause mild respiratory irritation.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated; however, monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; monitor for any allergic reactions. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use cautiously. |
| elderly | Low | Generally well tolerated; monitor for sensitivity. |
Toxicology Data
3 Endpoints
Dihydroterpinyl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human clinical study | No sensitization reactions | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Dihydroterpinyl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data on food safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Dihydroterpinyl Acetate
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Dihydroterpinyl Acetate
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Ingredients and Their Safety
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Dihydroterpinyl Acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in some individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
It is commonly used in fragrances, cosmetics, and food flavorings.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:14:38.261793Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.