10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
A-Terpinyl Acetate
Also known as: Terpinyl acetate, 1-Acetoxy-4-isopropenylcyclohexene
Molecular Formula
C12H20O2
Molecular Weight
196.29 g/mol
Category
fragrance
Bottom Line: A-Terpinyl Acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- used in well-ventilated areas
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical medications
- you have a history of allergies
✕ Avoid If:
- you are allergic to terpenes
- you have respiratory issues
- you are using on children under 2
- you experience irritation upon use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H20O2 |
| Molecular Weight | 196.29 g/mol |
| Boiling Point | 115.0°C |
| Log P | 2.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, beverages. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical ointments, medicated creams. Use with caution in medicinal products; consult a healthcare provider.
Supplement
Herbal supplements, aromatherapy oils. Consult a healthcare professional before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
A-Terpinyl Acetate is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal discomfort in some individuals, though toxicity is low.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically safe, but may cause mild respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse effects.
- pregnant — Limited safety data; use with caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- breastfeeding — Generally safe but consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
A-Terpinyl Acetate is assessed for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2014) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | EFSA Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
A-Terpinyl Acetate is assessed for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of A-Terpinyl Acetate
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on A-Terpinyl Acetate
Year: 2015
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on A-Terpinyl Acetate
Year: 2014
Conclusion: Safe for use in cosmetic products with appropriate concentration limits.
View Full Report →
Regulatory Status
Global
A-Terpinyl Acetate is permitted for use in cosmetics and food across major jurisdictions with some concentration limits. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Concentration limits apply in cosmetics
UK
UK GovernmentPERMITTED
Concentration limits apply in cosmetics
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is permitted as a flavoring agent in food, but should comply with local regulations.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:18:21.802137Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.