6.0
ISS Score
C — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · masking agent · odorant
Butylphenyl Methylpropional
Also known as: Lilial, p-tert-Butyl-alpha-methylhydrocinnamic aldehyde
Molecular Formula
C14H20O
Molecular Weight
204.31 g/mol
Category
fragrance ingredient
Bottom Line: Butylphenyl Methylpropional is generally considered safe in cosmetics, though some individuals may experience sensitivities. Its use is typically regulated in household products.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- part of a well-formulated product
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have a history of allergies
✕ Avoid If:
- you are allergic to fragrance ingredients
- you have eczema or dermatitis
- you experience irritation after use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H20O |
| Molecular Weight | 204.31 g/mol |
| Log P | 3.9 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in well-formulated products to minimize irritation risk.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products with this ingredient.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if you have skin sensitivities.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Dermal exposure to Butylphenyl Methylpropional may cause skin irritation in sensitive individuals.
oral
oral
Risk Level: High
Ingestion of Butylphenyl Methylpropional can lead to serious health effects and should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation, particularly in poorly ventilated areas.
ocular
ocular
Risk Level: Moderate
Eye contact with Butylphenyl Methylpropional can cause irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects from exposure.
- pregnant — Potential risks during pregnancy are concerning.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated but caution is advised.
- sensitive_skin — Use with caution; patch testing recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults may experience skin irritation or allergic reactions upon exposure. |
| pregnant | High | Limited data on effects during pregnancy; potential risks are concerning. |
| infants_children | Very High | Children may be more susceptible to adverse effects from exposure. |
| breastfeeding | Moderate | Potential for transfer through breast milk is not well studied. |
| sensitive_skin | High | Individuals with sensitive skin may experience heightened reactions. |
Toxicology Data
3 Endpoints
Butylphenyl Methylpropional is a fragrance ingredient with potential sensitization effects. Regulatory bodies assess its safety in various applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Sensitization | Positive in human patch tests | Human Patch Test | Moderate concern for sensitization | CIR Safety Assessment (2012) |
| LD50 Oral | Not established | Not available | Insufficient data | ECHA REACH Registration |
| Eye Irritation | Mildly irritating | Rabbit Eye Irritation Test | Low irritation potential | SCCS Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Butylphenyl Methylpropional is a fragrance ingredient with potential sensitization effects. Regulatory bodies assess its safety in various applications.
- Used widely in cosmetics and household products.
- Potential allergen for some individuals.
- Regulatory reviews indicate moderate safety concerns.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Butylphenyl Methylpropional
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Butylphenyl Methylpropional
Year: 2015
Conclusion: Not safe for use in cosmetics due to sensitization potential.
View Full Report →
FDA
Report: Regulatory Status of Fragrance Ingredients
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Regulatory status varies; permitted in the US and Canada, restricted in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Not allowed in cosmetics above 0.5%
United Kingdom
UK GovernmentRESTRICTED
Not allowed in cosmetics above 0.5%
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It is a synthetic fragrance ingredient commonly used in cosmetics and household products.
Generally safe in low concentrations, though some may experience allergic reactions.
Caution is advised; perform a patch test before full use to check for reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T06:45:27.221764Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.