7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
Methylcyclopentenolone
Molecular Formula
C6H8O2
Molecular Weight
112.13 g/mol
Category
fragrance
Bottom Line: Methylcyclopentenolone is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic products
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to fragrance ingredients
- Using on irritated or damaged skin
- Ingesting in large quantities
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C6H8O2 |
| Molecular Weight | 112.13 g/mol |
| Solubility | 1 g in 5 ml 90% alcohol (in ethanol) |
| Log P | 0.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical creams, ointments. Use with caution in sensitive formulations.
Supplement
Flavoring in dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methylcyclopentenolone is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal discomfort; limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause mild respiratory irritation; data is limited.
ocular
ocular
Risk Level: Very Low
Eye contact may cause mild irritation, but generally resolves quickly.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low risk.
- elderly — Typically low risk but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may react more strongly. |
Toxicology Data
3 Endpoints
Methylcyclopentenolone is a synthetic fragrance with limited safety data, primarily used in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Not sensitizing | Human patch test | Low sensitization potential | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methylcyclopentenolone is a synthetic fragrance with limited safety data, primarily used in cosmetics and food.
- Limited data on long-term exposure effects.
- Generally recognized as safe in low concentrations.
- Potential irritant for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methylcyclopentenolone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Methylcyclopentenolone
Year: 2018
Conclusion: Considered safe for use in cosmetics with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Methylcyclopentenolone is permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited to cosmetic use
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, it may cause irritation for those with sensitive skin. Patch testing is recommended.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
It is permitted for use in food flavoring, but should comply with local regulations.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:47:19.822882Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.