66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · antimicrobial agent · antioxidant · flavoring agent
Eugenia Caryophyllus Oil
Also known as: Clove Oil, Clove Bud Oil
Category
essential oil
Bottom Line: Eugenia Caryophyllus Oil is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in diluted form
- applied topically in small amounts
- used in food at recommended levels
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are allergic to cloves
✕ Avoid If:
- you have a known allergy to clove oil
- you are using it on broken skin
- you are taking anticoagulant medications
Chemical Properties
| Property | Value |
|---|---|
| Solubility | soluble in alcohol and oils |
Common Use Cases
4 Categories
Cosmetic
Facial creams, essential oil blends, massage oils. Dilute before applying to skin to avoid irritation.
Food
Spices, flavoring agents, herbal teas. Use in moderation as a flavoring agent.
Pharmaceutical
Topical analgesics, antiseptic formulations. Consult a healthcare provider before use in medicinal products.
Supplement
Capsules, liquid extracts. Follow dosage recommendations to avoid adverse effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Eugenia Caryophyllus Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Eugenia Caryophyllus Oil can be beneficial but may cause gastrointestinal discomfort in some cases.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of the oil is typically safe, but prolonged exposure may lead to respiratory irritation.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; use with caution.
- sensitive_skin — Increased likelihood of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally safe but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity to essential oils; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on effects during lactation; use cautiously. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Eugenia Caryophyllus Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity when used appropriately.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | CIR Safety Assessment (2012) |
| Sensitization | no sensitization observed | Human clinical study | Low sensitization potential | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Eugenia Caryophyllus Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity when used appropriately.
- Generally recognized as safe in food applications.
- Potential skin irritant if used undiluted.
- Antimicrobial properties noted in studies.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Eugenia Caryophyllus (Clove) Oil
Year: 2012
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of Eugenia Caryophyllus Oil
Year: 2015
Conclusion: Considered safe for use in food at specified levels.
View Full Report →
FDA
Report: Food Ingredients and Colors
Year: 2020
Conclusion: Generally recognized as safe when used in food.
View Full Report →
Regulatory Status
Global
Eugenia Caryophyllus Oil is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAGENERALLY RECOGNIZED AS SAFE
None
European Union
European CommissionPERMITTED IN COSMETICS AND FOOD
Follow usage guidelines
United Kingdom
UK GovernmentPERMITTED UNDER UK REGULATIONS
None
Canada
Health CanadaPERMITTED IN COSMETICS AND FOOD
Follow usage guidelines
Frequently Asked Questions
Generally, it is safe when diluted, but perform a patch test first to check for sensitivity.
Yes, it is recognized as safe for use in food at recommended levels, but moderation is key.
Avoid using it undiluted on the skin and if you have a known allergy to clove oil.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:07:45.920070Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.