8.0
ISS Score
C+ — Score based on regulatory approval status in 2 jurisdiction(s) and route-level risk assessment; no public toxicology studies available
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Humectant · Skin Conditioning Agent
Panthenol
Molecular Formula
C9H19NO4
Molecular Weight
189.26 g/mol
Category
Moisturizer
Bottom Line: Panthenol is generally considered safe for use in cosmetic formulations, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Formulated for topical application
- No known allergies to the ingredient
⚠ Use with Awareness If:
- You have sensitive skin
- You are using other active ingredients
- You experience irritation with new products
✕ Avoid If:
- You have a known allergy to Panthenol
- You experience adverse reactions
- You are using products with conflicting ingredients
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C9H19NO4 |
| Molecular Weight | 189.26 g/mol |
| Solubility | Soluble in water and alcohol |
Common Use Cases
1 Categories
Cosmetic
General products. Verify suitability for specific formulation and intended use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Panthenol is generally considered safe and well-tolerated in cosmetic formulations.
oral
oral
Risk Level: Insufficient Data
Oral safety data for Panthenol is limited. It is not typically ingested in cosmetic use.
inhalation
inhalation
Risk Level: Insufficient Data
Inhalation exposure data for Panthenol is insufficient. Use caution with aerosolized products.
ocular
ocular
Risk Level: Insufficient Data
Ocular exposure data for Panthenol is limited. Avoid contact with eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- Pregnant Individuals — Limited data on safety during pregnancy.
- Infants and Children — Safety data for infants and children is limited.
✔ Well-Tolerated Groups
- General Adult Population — Generally well-tolerated in cosmetic formulations.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| General Adult Population | Low | Generally well-tolerated in adults. Individual responses may vary. |
| Pregnant Individuals | Insufficient Data | Limited data on safety during pregnancy. Consult healthcare providers. |
| Infants and Children | Insufficient Data | Safety data for infants and children is limited. Individual reactions may vary. |
Toxicology Data
0 Endpoints
Panthenol is widely used in cosmetics and is generally regarded as safe based on available evidence.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Panthenol is widely used in cosmetics and is generally regarded as safe based on available evidence.
- Commonly used in moisturizers and hair products.
- Generally well-tolerated by most individuals.
- Limited data on specific population safety.
Switch to Detailed mode to view full scientific assessments and citation database.
Pending formal assessment
Report: No formal safety assessment identified
Year: 2026
Conclusion: This ingredient has not been formally assessed by major regulatory or scientific bodies based on available records.
Regulatory Status
Global
This ingredient is generally permitted for cosmetic use in major jurisdictions. Always verify current local regulations. Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionPERMITTED WITHOUT RESTRICTION IN COSMETICS
None specified
United States
FDAPERMITTED IN COSMETICS AND OTC DRUG PRODUCTS
None specified
Frequently Asked Questions
Panthenol is commonly used in cosmetics as a moisturizer and humectant, helping to retain moisture in skin and hair.
While Panthenol is generally well-tolerated, individuals with sensitive skin should perform a patch test before use.
There is limited data on the safety of Panthenol during pregnancy. It is advisable to consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| v1.0.0 | 2023-10-01T00:00:00Z | — | Initial creation |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.