7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · stabilizer
4-Cyclohexyl-2-Methylbutan-2-Ol
Molecular Formula
C11H22O
Molecular Weight
170.29 g/mol
Category
chemical compound
Bottom Line: 4-Cyclohexyl-2-Methylbutan-2-Ol is generally considered safe in cosmetics and pharmaceuticals, though caution is advised in sensitive populations.
Quick Answer
✔ Generally Safe If:
- used in concentrations below 1%
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation upon first use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H22O |
| Molecular Weight | 170.29 g/mol |
| Log P | 3.6 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in moderation and patch test before full application.
Pharmaceutical
Topical ointments, creams. Consult a healthcare provider for use in sensitive populations.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Supplement
Dietary supplements. Consult with a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 4-Cyclohexyl-2-Methylbutan-2-Ol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 4-Cyclohexyl-2-Methylbutan-2-Ol may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with 4-Cyclohexyl-2-Methylbutan-2-Ol may cause moderate irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity due to developing systems.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Low to moderate risk; monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children due to developing systems. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly may have increased sensitivity; monitor closely. |
Toxicology Data
3 Endpoints
4-Cyclohexyl-2-Methylbutan-2-Ol has limited safety data, but is generally regarded as safe in regulated uses.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
4-Cyclohexyl-2-Methylbutan-2-Ol has limited safety data, but is generally regarded as safe in regulated uses.
- Limited studies on long-term exposure.
- Generally safe in cosmetic formulations.
- Caution advised for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 4-Cyclohexyl-2-Methylbutan-2-Ol
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on 4-Cyclohexyl-2-Methylbutan-2-Ol
Year: 2022
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on 4-Cyclohexyl-2-Methylbutan-2-Ol
Year: 2023
Conclusion: Safe for use as a food additive within specified limits.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to cosmetic products only.
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:33:24.247090Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.